PittsburghV1, Main, Exploration, bibRecord, 000757

Zooming in on disordered systems: Neutron reflection studies of proteins associated with fluid membranes

Identifieur interne : 000757 ( Main/Exploration ); précédent : 000756; suivant : 000758

Zooming in on disordered systems: Neutron reflection studies of proteins associated with fluid membranes

Auteurs : Frank Heinrich ; Mathias Lösche

Source :

Biochimica et biophysica acta [ 0006-3002 ] ; 2014.

RBID : PMC:4082750

Descripteurs français

KwdFr :
- Double couche lipidique (), Humains, Modèles moléculaires, Neutrons, Peptides (), Protéines membranaires (), Simulation de dynamique moléculaire, Structure secondaire des protéines.
MESH :
- Double couche lipidique, Humains, Modèles moléculaires, Neutrons, Peptides, Protéines membranaires, Simulation de dynamique moléculaire, Structure secondaire des protéines.

English descriptors

KwdEn :
- Humans, Lipid Bilayers (chemistry), Membrane Proteins (chemistry), Models, Molecular, Molecular Dynamics Simulation, Neutrons, Peptides (chemistry), Protein Structure, Secondary.
MESH :
- chemical , chemistry : Lipid Bilayers, Membrane Proteins, Peptides.
- Humans, Models, Molecular, Molecular Dynamics Simulation, Neutrons, Protein Structure, Secondary.

Abstract

Neutron reflectometry (NR) is an emerging experimental technique for the structural characterization of proteins interacting with fluid bilayer membranes under conditions that mimic closely the cellular environment. Thus, cellular processes can be emulated in artificial systems and their molecular basis studied by adding cellular components one at a time in a well-controlled environment while the resulting structures, or structural changes in response to external cues, are monitored with neutron reflection. In recent years, sample environments, data collection strategies and data analysis were continuously refined. The combination of these improvements increases the information which can be obtained from NR to an extent that enables structural characterization of protein-membrane complexes at a length scale that exceeds the resolution of the measurement by far. Ultimately, the combination of NR with molecular dynamics (MD) simulations can be used to cross-validate the results of the two techniques and provide atomicscale structural models. This review discusses these developments in detail and demonstrates how they provide new windows into relevant biomedical problems.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082750

DOI: 10.1016/j.bbamem.2014.03.007
PubMed: 24674984
PubMed Central: 4082750

Affiliations:

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<front><div type="abstract" xml:lang="en"><p id="P1">Neutron reflectometry (NR) is an emerging experimental technique for the structural characterization of proteins interacting with fluid bilayer membranes under conditions that mimic closely the cellular environment. Thus, cellular processes can be emulated in artificial systems and their molecular basis studied by adding cellular components one at a time in a well-controlled environment while the resulting structures, or structural changes in response to external cues, are monitored with neutron reflection. In recent years, sample environments, data collection strategies and data analysis were continuously refined. The combination of these improvements increases the information which can be obtained from NR to an extent that enables structural characterization of protein-membrane complexes at a length scale that exceeds the resolution of the measurement by far. Ultimately, the combination of NR with molecular dynamics (MD) simulations can be used to cross-validate the results of the two techniques and provide atomicscale structural models. This review discusses these developments in detail and demonstrates how they provide new windows into relevant biomedical problems.</p>
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Zooming in on disordered systems: Neutron reflection studies of proteins associated with fluid membranes

Zooming in on disordered systems: Neutron reflection studies of proteins associated with fluid membranes

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur Pittsburgh
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